Lyric discussion by LIGHTPIE7 

I believe that some of the others were on the right track when they said Dr. John was referring to his drugs, but I believe it's more specifically about a man being pelted with one-night-stand upon one-night-stand who is turning to alcoholism and trying to find out where he went wrong.

(I look for joy in a strange place From the back of a bar, from afar See the look on my momma's face When her son's in the corner, undone)

He's trying to find solace in his pick-ups, but knows he's not likely to find anything. His loved ones try to support him but he turns them away.

(Oh, Dr. Johhhhn What am I doing? What am I doing wrong? 'Cause I keep on trying Something ain't going Something ain't going on)

He tries to turn to alcohol (Dr. John - Jack Daniels) to help "cure" him and find the right path in his life, which he realizes is less than ideal. He acknowledges that no matter what he does, he can't seem to find happiness in what he's doing right now.

You can tell that it's not just alcoholism, but a combination of that and a history of one-night-stands from some of the other lines. "Another day, another break-up" in particular. But that's just my take on it.

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