Lyric discussion by nothing2lose 

yea this song is about touring.. but i think its more just about drug addiction.. i mean it comes out and says it

What in the world ever became of sweet Jane? She lost her sparkle, you know she isn't the same Living on reds, vitamin C and cocaine all a friend can say is "ain't it a shame"

There it says that pot just doesnt do it for him anymore. So he turns to harder drugs like reds which is a barbituate called Seconal, vitamin C is Ketamine and coke..

Then i think there are just a lot of things that can either be interpreted as touring or drug addiction so the rest is up to you

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