Holmes is known for writing "Dazed and Confused," which was later adapted and popularized by Jimmy Page of The Yardbirds and Led Zeppelin. The song appeared on Holmes' debut, "The Above Ground Sound" of Jake Holmes. Led Zeppelin does not credit Holmes with authorship of their song.

It is still not widely recognized that Holmes was the author of the classic song. Page, while on tour with the Yardbirds in 1967, saw Holmes perform the song in Greenwich Village. Within months, he had adapted the song for that group, and later, for Led Zeppelin. For reasons that are not entirely clear, Page claimed sole songwriting credit for the song when it appeared on Led Zeppelin's debut album. Holmes later sent Page a letter about the songwriting credits but received no reply.

In June 2010, Holmes filed a lawsuit against Jimmy Page for copyright infringement in United States District Court, claiming Page knowingly copied his work.

November 2012's release of Celebration Day (The Led Zeppelin Reunion Show at the O2) credits "Dazed and Confused" as written by Jimmy Page inspired by Jake Holmes.